MARTINEZ Jean
Fonction : DU - UMR5247
Thème de Recherche: exter
martinez
univ-montp1.fr
0411759601
Dernieres Publications:
|
|
Environmentally benign peptide synthesis using liquid-assisted ball-milling: application to the synthesis of Leu-enkephalin† 
Auteur(s): BONNAMOUR J., METRO T.-x., MARTINEZ J., LAMATY F.
(Article) Publié:
Green Chemistry, vol. 15 (2013) p.1116-1120
Ref HAL: hal-00820792_v1
DOI: 10.1039/c3gc40302e
Résumé: This paper describes an original methodology for peptide bond synthesis avoiding toxic solvents and reactants. Ball-milling stoichiometric amounts of Boc-protected α-amino acid N-carboxyanhydrides (Boc-AA-NCA) or Boc-protected α-amino acid Nhydroxysuccinimide esters (Boc-AA-OSu) with α-amino acid alkyl ester salts in the presence of NaHCO3 and a minimal quantity of EtOAc led to the production of di- to pentapeptides in an efficient and environmentally benign manner. This approach was successfully applied to the synthesis of Leu-enkephalin.
|
|
|
|
Palladium N-Heterocyclic Carbene Catalysts for the Ultrasound-Promoted Suzuki-Miyaura Reaction in Glycerol
Auteur(s): Azua Arturo, Mata Jose.A, Heymes Pauline, Peris Eduardo, LAMATY F., MARTINEZ J., COLACINO E.
(Article) Publié:
Synthesis, vol. 355 (2013) p.1107-1116
Ref HAL: hal-00820777_v1
DOI: 10.1002/adsc.201201047
Résumé: Novel palladium N-heterocyclic-carbene (NHC)-based complexes with 3,4,5-trimethoxybenzyl, alkyl and sulfonate N-substituents were obtained and fully characterized. The new complexes were used as pre-catalysts in the Suzuki-Miyaura coupling of various aryl halides/boron sources in glycerol under pulsed-ultrasound (P-US) activation. High yields were obtained under mild reaction conditions, without formation of undesired by-products. The pure final cross-coupling products were easily recovered without column chromatography and the catalytic/ solvent system could be recycled. TEM (transmission electron microscopy) and XPS (X-ray photoelectron spectroscopy) were used to characterize the nanoparticles and to investigate the fate of the catalysts.
|
|
|
|
Synthesis of Pyrrolin-4-ones by Pt-Catalyzed Cycloisomerization in PEG under Microwaves
Auteur(s): SPINA R., COLACINO E., Gabriele Bartolo, Salerno Giuseppe, MARTINEZ J., LAMATY F.
(Article) Publié:
The Journal of Organic Chemistry, vol. 78 (2013) p.2698-2702
Ref HAL: hal-00802298_v1
DOI: 10.1021/jo3024r
Résumé: The unprecedented eco-friendly Pt-catalyzed 5endo-dig cycloisomerization of readily available α-amino ynones is reported under microwave irradiation in PEG-3400 as reaction matrix. The corresponding pure pyrrolin-4-ones were obtained in excellent yields (80−98%) directly after a straightforward precipitation−filtration workup, thus avoiding any chromatographic purification. The catalytic system was recycled and the chiral purity of all the products was also investigated.
|
|
|
|
Poly(ethylene glycol) as a Reaction Matrix in Platinum- or Gold-Catalyzed Cycloisomerization: A Mechanistic Investigation
Auteur(s): SPINA R., COLACINO E., MARTINEZ J., LAMATY F.
(Article) Publié:
-Chemistry A European Journal, vol. 19 (2013) p.3817-3821
|
|
|
|
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.
Auteur(s): Schaeffer Marie, Langlet Fanny, Lafont Chrystel, MOLINO François, Hodson David j, VERDIE P., Dehouck Bénédicte, BANERES J.-l., MARTINEZ J., Méry Pierre-François, MARIE J., FEHRENTZ J.-a., Prévot Vincent, Mollard Patrice
(Article) Publié:
Proceedings of the National Academy of Sciences of the United States of America, vol. 110 (2013) p.1512-7
Ref HAL: hal-00796900_v1
PMID 23297228
DOI: 10.1073/pnas.1212137110
Résumé: To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood-brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central hypothalamic neurons remains largely unexplored. Using in vivo multiphoton microscopy together with fluorescently labeled ligands, we demonstrate that circulating ghrelin, a versatile regulator of energy expenditure and feeding behavior, rapidly binds neurons in the vicinity of fenestrated capillaries, and that the number of labeled cell bodies varies with feeding status. Thus, by virtue of its vascular connections, the hypothalamus is able to directly sense peripheral signals, modifying energy status accordingly.
|
Plus...
Calcpeg
Chemaztech
