Ref HAL: hal-00722471_v1
DOI: 10.1039/c2py20309j
Résumé: The present contribution reports on an original new class of acid-labile thermosensitive polyacrylamides, namely poly(tris(hydroxymethyl)acrylamidomethane-co-(5-acrylamido-5-hydroxymethyl-2,2-dimethyl-1,3-dioxane)) (P(THAM-co-pTHAM)), in which pTHAM only differed from THAM by an acetal group. The lower critical solution temperature (LCST) was controlled by varying the comonomer composition. Additionally, the properties of these new statistical copolymers were investigated and proved that such chemical structures were interesting for smart applications, notably for drug delivery due to the biocompatibility of low molecular weight PTHAM already demonstrated.

Ref HAL: hal-00717310_v1
DOI: 10.1039/c2py20054f
Résumé: Diffusion-ordered spectroscopy (DOSY)NMRwas successfully used to characterize amphiphilic block copolymers. A triblock copolymer was prepared by ring-opening polymerisation of a lactide using poly(ethylene glycol) as the initiator. The DOSY NMR experiment is revealed to be a useful analytical method to prove the formation of block copolymers. According to the DOSY map, PLA and PEG blocks exhibited the same diffusion coefficient of 5.623 10 10 m2 s 1, consistent with an efficient polymerisation of the lactide. The determination of the critical micelle concentration (CMC) using DOSY NMR experiments has also been reported. The CMC value correlated with those obtained by fluorimetry and static light scattering. The CMC value was found to be 0.11 g L 1. All the results suggest that DOSY NMR is a valuable analytical tool for the polymer community. The good correlation between the results from DOSY, fluorescence and SLS experiments suggests that the DOSY spectroscopy can accurately measure the CMC of amphiphilic copolymer solutions.

Ref HAL: hal-00672344_v1
DOI: 10.1039/c1py00414j
Résumé: A straightforward approach based on thiol-ene click chemistry was used to prepare novel functional polyesters containing amino groups. First, a series of well-defined alkene-functional poly(3caprolactone)s were prepared by ring-opening polymerization of a-allyl-3-caprolactone with 3caprolactone in toluene and in bulk using tin 2-ethylhexanoate as catalyst. These functional polyesters were fully characterized http://hal.archives-ouvertes.fr/index.php?action_todo=submit&halsid=qmsa1qonrofgk66ln1k5h23cd4by 1H NMR, GPC, and MALDI-TOF MS. The resulting random copolyesters were obtained with a wide range of molar masses from3000 to 50 000 g mol

Ref HAL: hal-00671757_v1
DOI: 10.1039/c2cc30191a
Résumé: Well-defined graft copolymers were obtained using a coppercatalysed azide-alkyne Huisgen's cycloaddition click reaction from both biocompatible and non-toxic poly(e-caprolactone) and poly(2-methyl-2-oxazoline) homopolymers. Resulting amphiphilic copolymers proved to form micelles that could be used as potential drug carriers.

Ref HAL: hal-00626805_v1
DOI: 10.1002/adfm.20110042
Résumé: Biodegradable aliphatic polyesters such as polylactide (PLA) are widely used in medical applications. When employed as an implantable material, the control of the surface properties of PLA is of great interest because biochemical reactions occur on the surface or at interfaces. Thus, chemical modifi cations of the surface of degradable polyesters can be used to tailor the surface properties while preserving the bulk characteristics. This paper proposes a simple and versatile method of preventing polymer degradation and immobilizing simple molecules, macromolecules, and biomolecules on PLA surfaces. The method is based on a one-pot, two-step procedure: anionic activation under selected conditions followed by propargylation to form a "clickable" PLA surface. This surface is extensively characterized by SEC and fl uorescence techniques using a fl uorescent probe, confi rming both the functionalization and the absence of PLA degradation. An example of the surface immobilization of a bioactive compound is then described: a well-defi ned Éø -azido-functionalized poly(quaternary ammonium) synthesized via ATRP is covalently bound to the propargylated PLA surface using "click" chemistry. This covalent grafting is confi rmed by SEC and XPS analyses. The increase in surface hydrophilicity is demonstrated by water contact-angle measurements. Finally, a primary investigation is conducted to determine the antibacterial activity of modifi ed PLA surfaces against E. coli and S. aureus .