Chemistry of Amino Acids, Peptides, Heterocycles, Supported Chemistry
Enzyme inhibitors and substrates.
- Alzheimer’s disease: proteases involved in the production of b-amyloid peptide.
- Malaria: SUB-2, Plasmodium protease involved in the invasion of erythrocytes by the parasite.
- Type-II diabetes: inducible NO Synthase, involved in insulin resistance.
- Leishmaniosis: Leishmania HsIVU, proteasome-type complex.
Cancer.
- Vectorisation of an anticancerous drug by using a protease overexpressed by certain tumours.
- Inhibition of kinases.
Synthesis of amino-acids, peptidomimetics, heterocycles - Neuro-exciting amino acids
- turn mimics
- Heterocycles (benzopyranes, benzazepines, pyrroles…)
High-throughput chemistry – Combinatorial chemistry
- Methodology of supported chemistry (soluble and insoluble polymers)
- Chemical platforms for combinatorial chemistry
- Multi-component reactions (MCRs)
Organometallic chemistry;
- Organozincics and organocuprates
- Palladium catalysed reactions
- Metathesis
Green chemistry
- Solvent free reaction (mechanochemical activation)
- Microwave-induced activation
- Use of PEG as a solvent in organic synthesis
Synthesis methodology on solid support: cyclic peptides, pseudo-peptides, heterocycles, enzyme inhibitors.
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In the same section :
- Glycochemistry - Molecular Recognition
- Modified Oligonucleotides
- Nucleosides & Phosphorylated Effectors
- Biopolymers
- Biomolecular Organisation
- Bioactive and Antimalarial Lipids
- Stereoselective syntheses & modified amino acids
- Cellular pharmacology
- The Automated Analysis and Synthesis Platform
- Analytic Sciences of Biomolecules & Molecular Modelling
